Description

Methoxy-Peg-Propionicacid-n-Succinimidylester is a heterobifunctional polyethylene glycol (PEG) derivative, widely used as a versatile linker in bioconjugation chemistry. Its core value lies in enabling the stable and site-specific attachment of molecules, such as drugs, peptides, or fluorophores, to biological targets like antibodies or proteins. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries who are developing advanced therapeutics, including antibody-drug conjugates (ADCs), PEGylated proteins, and biosensors.

Application

• Antibody-Drug Conjugate (ADC) Development: A key reagent for linking cytotoxic payloads to monoclonal antibodies via amine groups.
• Protein and Peptide PEGylation: Used to modify therapeutic proteins to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Diagnostic Probe Conjugation: Facilitates the labeling of antibodies, enzymes, or other proteins with fluorescent dyes, enzymes, or other detection tags for immunoassays and imaging.
• Surface Functionalization: Employed to modify nanoparticles, microspheres, or sensor surfaces with active ester groups for subsequent biomolecule immobilization.
• Cross-linking and Bioconjugation Kits: A critical component in commercial and in-house kits designed for facile and efficient biomolecule cross-linking.
• Polymer Therapeutics: Serves as a building block for creating sophisticated, multi-functional polymer-drug conjugates.

Basic Information

Product Name	Methoxy-Peg-Propionicacid-n-Succinimidylester
CAS No.	174569-25-6
Molecular Formula	CnH2n+1Om (Variable based on PEG chain length 'n')
Molecular Weight	Variable (Contact for details on specific PEG chain length, e.g., 5kDa, 10kDa, 20kDa)
Synonyms	mPEG-SPA; mPEG-Succinimidyl Propionate; Methoxy PEG Succinimidyl Propionate; Methoxy Polyethylene Glycol Succinimidyl Propionate; α-Methoxy-ω-succinimidyl propionate PEG; NHS-PEG-OMe; SCM-PEG-OMe; PEG-NHS Ester
EINECS	Contact for details

Quality Control

Our Methoxy-Peg-Propionicacid-n-Succinimidylester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and functional group analysis, to ensure high purity, consistent molecular weight, and optimal reactivity. Certificates of Analysis (COA) detailing purity, substitution efficiency, and endotoxin levels (where applicable) are provided with every shipment to support your research and cGMP-compliant manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Complies
PEG Chain Length (n)	As specified (e.g., 5kDa, 10kDa, 20kDa)
Purity (HPLC)	≥ 95%
Functional Substitution	≥ 90%
Moisture Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.