Description

5-Cyanopyridine-2-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive sulfonyl chloride and cyano functional groups. This compound is essential for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel sulfonamide derivatives and heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors and antimicrobial agents.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of activity-based probes (ABPs).
• Dye & Pigment Industry: Intermediate for creating advanced colorants and photographic chemicals.
• Custom Synthesis & Contract Manufacturing: A critical reagent for research organizations and CROs/CMOs engaged in custom chemical synthesis projects.

Basic Information

Product Name	5-Cyanopyridine-2-Sulfonyl Chloride
CAS No.	174486-12-5
Molecular Formula	C6H3ClN2O2S
Molecular Weight	202.62 g/mol
Synonyms	2-Pyridinesulfonyl chloride, 5-cyano-; 5-Cyano-2-pyridinesulfonyl chloride; 5-Cyanopyridine-2-sulfonyl chloride; 2-Chlorosulfonyl-5-cyanopyridine; 5-Cyano-2-pyridylsulfonyl chloride; 5-Cyanopyridin-2-ylsulfonyl chloride; 174486-12-5; 5-CN-Py-2-SO2Cl
EINECS	Contact for details

Quality Control

Our 5-Cyanopyridine-2-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to meet the stringent requirements of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.