Description

1,4-Dioxaspiro[4.4]Nonane-6-Carboxylicacid,6-Fluoro-,(+)-(9Ci) is a high-purity, chiral fluorinated spirocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a fused dioxolane ring and a carboxylic acid handle, makes it a valuable intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, where the introduction of fluorine can dramatically alter biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the spirocyclic and fluorinated motifs can enhance efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products or biomarkers for metabolic and mechanistic studies.

Basic Information

Product Name	1,4-Dioxaspiro[4.4]Nonane-6-Carboxylicacid,6-Fluoro-,(+)-(9Ci)
CAS No.	174405-54-0
Molecular Formula	C9H11FO4
Molecular Weight	202.18 g/mol
Synonyms	(+)-6-Fluoro-1,4-dioxaspiro[4.4]nonane-6-carboxylic acid; (6R)-6-Fluoro-1,4-dioxaspiro[4.4]nonane-6-carboxylic acid; 6-Fluoro-1,4-dioxaspiro[4.4]nonane-6-carboxylic acid, (+)-; Fluorinated spirocyclic acid; (R)-6-Fluoro-1,4-dioxaspiro[4.4]nonane-6-carboxylic acid; 174405-54-0; Spiro[1,3-dioxolane-2,6'-bicyclo[3.2.0]heptane]-6'-carboxylic acid, 6'-fluoro-, (1'R,5'R)-
EINECS	Contact for details

Quality Control

Our production of 1,4-Dioxaspiro[4.4]Nonane-6-Carboxylicacid,6-Fluoro-,(+)-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO 9001 standards for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.