Description

1-(tert-Butoxycarbonyl)Piperidine-4-Carboxylic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical key building block in the development of complex pharmaceutical molecules and bioactive compounds. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for constructing peptide mimetics and other sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and other therapeutic areas.
• Peptidomimetic Synthesis: Used to introduce the piperidine-4-carboxylic acid scaffold into peptide backbones, creating molecules with enhanced metabolic stability and bioavailability.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for the amine functionality during multi-step synthetic sequences.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and insecticides with specific mode-of-action profiles.
• Ligand and Catalyst Development: Employed in the creation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Used to synthesize labeled compounds and molecular probes for studying biological pathways and protein interactions.

Basic Information

Item	Details
Product Name	1-(tert-Butoxycarbonyl)Piperidine-4-Carboxylic Acid
CAS No.	174286-31-8
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	1-Boc-piperidine-4-carboxylic acid; 4-(Boc-amino)piperidine-4-carboxylic acid; 1-N-Boc-isonipecotic acid; Piperidine-4-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; 1-tert-Butoxycarbonyl-4-piperidinecarboxylic acid; Boc-4-piperidinecarboxylic acid; Boc-Pip-OH
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	142 - 148 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.