Description

3-Chloro-4-Hydroxypiperidin-2-One is a versatile and highly functionalized piperidinone derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both chloro and hydroxyl substituents, makes it an invaluable intermediate for constructing complex molecules with precise stereochemistry. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in neurological and psychiatric therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in enantioselective catalytic reactions.
• Chemical Biology Probe Development: Utilized in medicinal chemistry to create tool compounds for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	3-Chloro-4-Hydroxypiperidin-2-One
CAS No.	174204-83-2
Molecular Formula	C5H8ClNO2
Molecular Weight	149.57 g/mol
Synonyms	3-Chloro-4-hydroxypiperidin-2-one; 2-Piperidinone, 3-chloro-4-hydroxy-; 3-Chloro-4-hydroxy-2-piperidinone; 4-Hydroxy-3-chloro-2-piperidinone; 3-Chloro-4-hydroxypiperidinone; 3-Chloro-4-hydroxy-2-piperidone; (3-Chloro-4-hydroxy-2-oxopiperidin-1-yl); 174204-83-2
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Hydroxypiperidin-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity (enantiomeric excess), and identification by spectroscopic methods (NMR, IR, MS). A Certificate of Analysis (COA) detailing all specifications is supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.