Description

(R)-Homocitric Acid Lactone CAS NO 173934-26-4 is a chiral, non-proteinogenic organic acid derivative that serves as a key intermediate and building block in advanced organic synthesis. Its defined stereochemistry is critical for applications in pharmaceutical research and the development of bioactive compounds. This high-purity specialty chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs) and complex natural product analogs.
• Biochemical Research: Used as a precursor or standard in metabolic pathway studies, particularly those involving lysine biosynthesis or citric acid cycle analogs.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereoselective reactions to construct molecules with defined three-dimensional architecture.
• Agrochemical Development: Serves as an intermediate in the research and production of enantiomerically pure herbicides, fungicides, or plant growth regulators.
• Fine Chemical Synthesis: A valuable reagent for the preparation of specialty chemicals, flavors, and fragrances where stereochemical purity is paramount.
• Academic & Industrial R&D: Utilized in discovery chemistry for creating libraries of chiral compounds with potential biological activity.

Basic Information

Product Name	(R)-Homocitric Acid Lactone
CAS No.	173934-26-4
Molecular Formula	C7H8O6
Molecular Weight	188.13 g/mol
Synonyms	(R)-Homocitric Acid γ-Lactone; (3R)-3,4-Dihydroxy-4-carboxybutanoic acid γ-lactone; (R)-2-Oxepanone-3,4-diol; (R)-Homocitric acid 1,4-lactone; D-Homocitric acid lactone; (R)-HCA lactone; (3R)-Tetrahydro-2-oxo-3-furancarboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-Homocitric Acid Lactone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and titration for assay determination. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is stable under these conditions but should be kept away from strong bases and organic solvents as indicated by its chemical properties. For long-term storage, consider inert atmosphere packaging to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.