Description

Penostatin A is a specialized, high-purity chemical compound identified by CAS NO 173485-70-6, primarily recognized for its role as a potent and selective inhibitor of protein prenylation. This compound matters to researchers and developers because it serves as a critical tool for studying cellular signaling pathways, particularly those involving Ras and Rho GTPase families, which are central to understanding cell growth and proliferation. It is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on oncology, cardiovascular disease, and metabolic disorder research, where precise pathway modulation is required for drug discovery and mechanistic studies.

Application

• Biochemical Research: A key reagent for investigating the mechanisms of protein prenylation and its role in membrane association and protein function.
• Oncology Studies: Used in cancer research to inhibit oncogenic Ras signaling pathways, aiding in the development of targeted anti-cancer therapies.
• Signal Transduction Analysis: Employed as a selective tool compound to dissect and validate specific nodes within complex cellular signaling networks.
• Pharmaceutical Screening: Serves as a reference standard or active compound in high-throughput screening assays for drug discovery programs.
• Academic Research: Utilized in university and institutional labs for fundamental studies in cell biology, enzymology, and molecular pharmacology.
• Biomarker Development: Supports research into identifying and validating prenylation status as a potential biomarker for certain disease states.

Basic Information

Product Name	Penostatin A
CAS No.	173485-70-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Penostatin A; FTI-277; (2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2R)-2-Acetamido-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid; Prenylation Inhibitor I; Ras Farnesyltransferase Inhibitor I
EINECS	Contact for details

Quality Control

Every batch of Penostatin A is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for key parameters such as assay purity and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider keeping the product under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Assay (HPLC)	≥95.0%
Water Content	≤1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.