Description

(4-Iodo-Benzyl)-Phosphonic Acid Diethyl Ester is a high-purity organophosphorus compound featuring a reactive iodo-benzyl moiety. This specialized chemical serves as a critical building block in advanced organic synthesis, enabling the introduction of phosphonate and aryl iodide functional groups. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of bioactive molecules, particularly for creating phosphonate-based prodrugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that incorporate phosphonate ester groups.
• Ligand and Catalyst Development: Serves as a versatile starting material for constructing complex phosphonate-containing ligands for metal catalysis.
• Material Science Research: Employed in the synthesis of functionalized monomers for polymers and advanced materials with specific surface properties.
• Cross-Coupling Reactions: The aryl iodide group makes it a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form carbon-carbon bonds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	(4-Iodo-Benzyl)-Phosphonic Acid Diethyl Ester
CAS No.	173443-43-1
Molecular Formula	C11H16IO3P
Molecular Weight	354.12 g/mol
Synonyms	Diethyl (4-Iodobenzyl)phosphonate; (4-Iodobenzyl)phosphonic Acid Diethyl Ester; Diethyl P-[(4-Iodophenyl)methyl]phosphonate; Phosphonic Acid, P-[(4-Iodophenyl)methyl]-, Diethyl Ester; Diethyl (4-Iodobenzyl)phosphonite (common misnomer); 4-Iodobenzylphosphonic Acid Diethyl Ester; Diethyl (p-Iodobenzyl)phosphonate
EINECS	Contact for details

Quality Control

Our (4-Iodo-Benzyl)-Phosphonic Acid Diethyl Ester is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. For custom synthesis or specific grade requirements, our technical team is available to discuss tailored quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.