Description

3-Amino-2-Chloro-Isonicotinic Acid Methyl Ester is a high-purity, functionalized pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique substitution pattern, which enables the construction of complex heterocyclic systems and active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging its heterocyclic core for bioactivity.
• Ligand Synthesis: Serves as a starting material for creating specialized ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Complex Heterocycle Construction: Integral for building fused pyridine and isoquinoline derivatives with potential biological activity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Amino-2-Chloro-Isonicotinic Acid Methyl Ester
CAS No.	173435-41-1
Molecular Formula	C7H7ClN2O2
Molecular Weight	186.60 g/mol
Synonyms	Methyl 3-Amino-2-Chloroisonicotinate; 2-Chloro-3-Amino-4-Pyridinecarboxylic Acid Methyl Ester; 3-Amino-2-Chloro-4-(Methoxycarbonyl)pyridine; 2-Chloro-3-Aminopyridine-4-Carboxylic Acid Methyl Ester; Methyl 2-Chloro-3-Aminopyridine-4-Carboxylate; 4-Pyridinecarboxylic Acid, 3-Amino-2-Chloro-, Methyl Ester; 173435-41-1
EINECS	Contact for details

Quality Control

Our 3-Amino-2-Chloro-Isonicotinic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.