Description

Ethyl n-Cbz-3-Amino-2,2-Dimethylpropanoate is a high-purity, protected amino acid ester derivative designed for advanced organic synthesis. This compound serves as a critical building block for the controlled introduction of sterically hindered amino acid motifs into target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and biotechnology sectors for the synthesis of novel peptides, peptidomimetics, and other bioactive compounds requiring specific structural features.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new Active Pharmaceutical Ingredients (APIs), particularly for peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a sterically hindered, Cbz-protected 3-amino-2,2-dimethylpropanoic acid residue.
• Prodrug Development: Employed in the design and synthesis of prodrugs where the ethyl ester moiety can be cleaved enzymatically in vivo.
• Chemical Biology Research: Serves as a tool compound for studying enzyme inhibition, receptor binding, and other biological mechanisms.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects for clients.
• Academic Research: Utilized in university and institutional labs for methodological development in organic chemistry and medicinal chemistry.

Basic Information

Product Name	Ethyl n-Cbz-3-Amino-2,2-Dimethylpropanoate
CAS No.	173336-49-7
Molecular Formula	C15H21NO4
Molecular Weight	279.33 g/mol
Synonyms	Ethyl 3-[[(Benzyloxy)carbonyl]amino]-2,2-dimethylpropanoate; 3-[(Benzyloxycarbonyl)amino]-2,2-dimethylpropionic Acid Ethyl Ester; N-Cbz-3-Amino-2,2-dimethylpropionic Acid Ethyl Ester; Ethyl 3-(Cbz-amino)-2,2-dimethylpropionate; N-Carbobenzoxy-3-amino-2,2-dimethylpropionic Acid Ethyl Ester; (3-(((Benzyloxy)carbonyl)amino)-2,2-dimethylpropanoic acid ethyl ester; Z-3-Amino-2,2-dimethylpropionic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl n-Cbz-3-Amino-2,2-Dimethylpropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.