Description

2(3H)-Furanone, 5-[(1S,3S)-1-Azido-3-(Hydroxymethyl)-4-Methylpentyl]Dihydro-3-(1-Methylethyl)-, (3S,5S)- is a high-purity, stereochemically defined chiral building block featuring a unique furanone core with azido and hydroxymethyl functional groups. This compound is of significant value in advanced organic synthesis, particularly for applications requiring precise molecular architecture and click chemistry compatibility. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially protease inhibitors and other biologically active molecules.
• Click Chemistry Reagent: The azido group enables efficient Huisgen 1,3-dipolar cycloaddition reactions for bioconjugation, polymer modification, and material science applications.
• Agrochemical Synthesis: Used in constructing complex molecular scaffolds for novel pesticides and herbicides with specific stereochemical requirements.
• Natural Product Analog Synthesis: Serves as a building block for the total synthesis or semi-synthesis of complex natural products and their derivatives.
• Peptidomimetic Research: The furanone moiety can act as a dipeptide or turn mimetic in the design of novel peptide-based therapeutics.
• Material Science & Polymer Chemistry: Incorporated into specialty polymers to introduce specific functional groups or chiral centers into the polymer backbone.

Basic Information

Product Name	2(3H)-Furanone, 5-[(1S,3S)-1-Azido-3-(Hydroxymethyl)-4-Methylpentyl]Dihydro-3-(1-Methylethyl)-, (3S,5S)-
CAS No.	173154-03-5
Molecular Formula	C15H25N3O3
Molecular Weight	295.38 g/mol
Synonyms	(3S,5S)-5-[(1S,3S)-1-Azido-3-(hydroxymethyl)-4-methylpentyl]dihydro-3-isopropyl-2(3H)-furanone; (3S,5S)-3-Isopropyl-5-[(1S,3S)-1-azido-3-(hydroxymethyl)-4-methylpentyl]dihydrofuran-2(3H)-one; Chiral Azido Hydroxymethyl Furanone; Azido-functionalized Chiral Lactone; Furanone-based Chiral Azide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this advanced chiral intermediate is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC/NMR), chiral purity, and residual solvent content is provided with each shipment to ensure full traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to the presence of an azido group, standard safety precautions for azide compounds should be observed. Keep away from heat, sparks, open flames, and strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.