Description

3-Pyridinethiol, 4-Amino-, (Hydrochloride) (1:1) is a specialized heterocyclic building block featuring both amino and thiol functional groups on a pyridine core, stabilized as a hydrochloride salt. This compound is a critical intermediate for synthesizing complex molecules, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for creating novel drug candidates, especially in areas like kinase inhibitors and other targeted therapies. Its unique structure offers versatile reactivity for constructing sophisticated nitrogen and sulfur-containing scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its heterocyclic structure for bioactivity.
• Chemical Biology & Proteomics: Serves as a precursor for designing activity-based probes, affinity labels, or bioconjugation reagents due to its reactive thiol and amino groups.
• Material Science: Potential monomer or ligand for constructing functional polymers, metal-organic frameworks (MOFs), or catalysts.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploratory synthesis in medicinal chemistry.

Basic Information

Product Name	3-Pyridinethiol, 4-Amino-, (Hydrochloride) (1:1)
CAS No.	173069-45-9
Molecular Formula	C5H7N2S • HCl
Molecular Weight	162.65 g/mol (Free base: 126.19 g/mol)
Synonyms	4-Amino-3-mercaptopyridine hydrochloride; 4-Amino-3-pyridinethiol hydrochloride; 3-Mercapto-4-aminopyridine HCl; 4-Amino-3-pyridyl mercaptan hydrochloride; 4-Amino-3-thiolpyridine hydrochloride; 3-Pyridinethiol, 4-amino-, monohydrochloride; 4-Amino-3-sulfanylpyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Pyridinethiol, 4-Amino-, (Hydrochloride) (1:1) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent oxidation and moisture uptake. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.