Description

Methyl 2-(Benzyloxycarbonylamino)-2-Methylpropanoate is a protected amino acid derivative, specifically a Cbz-protected α-methyl alanine methyl ester, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a sterically hindered, enantiomerically pure scaffold that is essential for constructing complex peptide mimetics and active pharmaceutical ingredients (APIs). This high-purity intermediate is critically needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and peptide-based drugs.
• Peptidomimetics Research: Essential building block for creating non-natural amino acid residues in peptidomimetic compounds to enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting specific proteases (e.g., HCV NS3/4A protease).
• Asymmetric Synthesis: Serves as a starting material or intermediate in asymmetric catalytic processes to introduce quaternary stereocenters.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	Methyl 2-(Benzyloxycarbonylamino)-2-Methylpropanoate
CAS No.	172992-10-8
Molecular Formula	C13H17NO4
Molecular Weight	251.28 g/mol
Synonyms	Methyl 2-[(benzyloxy)carbonylamino]-2-methylpropanoate; Cbz-α-methylalanine methyl ester; (Benzyloxycarbonylamino)-α-methylalanine methyl ester; Z-Aib-OMe; N-Carbobenzoxy-α-aminoisobutyric acid methyl ester; Methyl N-(benzyloxycarbonyl)-2-aminoisobutyrate; 2-[(Benzyloxycarbonyl)amino]-2-methylpropanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-(Benzyloxycarbonylamino)-2-Methylpropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment. We support development and commercial projects with material suitable for research use through to cGMP-grade supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% e.e.
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.