Description

1-Pyrrolidinecarboxylic Acid, 2-(Chlorocarbonyl)-5-Oxo-, Methyl Ester, (S)- (9Ci) is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its core value proposition lies in its role as a key precursor for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for complex organic synthesis and process development.

Application

This specialized intermediate is utilized in sophisticated synthetic pathways across several high-value industries.

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of novel APIs, including protease inhibitors and other biologically active compounds.
• Peptide Mimetic Synthesis: Used in the construction of peptidomimetics and constrained amino acid analogs for drug discovery programs.
• Agrochemical Research: Serves as a building block for developing new generation pesticides and herbicides with specific stereochemical requirements.
• Catalyst and Ligand Development: Employed in the synthesis of novel chiral catalysts and ligands for asymmetric synthesis.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and process chemistry optimization.

Basic Information

Item	Details
Product Name	1-Pyrrolidinecarboxylic Acid, 2-(Chlorocarbonyl)-5-Oxo-, Methyl Ester, (S)- (9Ci)
CAS No.	172988-55-5
Molecular Formula	C8H10ClNO4
Molecular Weight	219.62 g/mol
Synonyms	(S)-2-(Chlorocarbonyl)-5-oxo-1-pyrrolidinecarboxylic acid methyl ester; Methyl (S)-2-(chlorocarbonyl)-5-oxopyrrolidine-1-carboxylate; (S)-N-Methoxycarbonyl-2-chlorocarbonyl-γ-butyrolactam; (S)-1-(Methoxycarbonyl)-5-oxopyrrolidine-2-carbonyl chloride; 172988-55-5; (S)-N-Cbz-2-chlorocarbonyl-γ-butyrolactam
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We operate under a quality management system and can support development projects requiring ICH stability data or custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to maintain stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.