Description

Bicyclo[3.1.0]Hexane-1-Carboxylic Acid, 4-Hydroxy-, Methyl Ester, (1Alpha,4Beta,5Alpha)- is a high-purity, stereochemically defined bicyclic compound that serves as a critical chiral building block and synthetic intermediate. Its unique fused ring structure and functional groups make it valuable for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the construction of advanced, stereospecific pesticide and herbicide molecules to enhance efficacy and environmental profile.
• Medicinal Chemistry Research: Employed as a versatile scaffold for library synthesis and structure-activity relationship (SAR) studies due to its constrained geometry.
• Process Chemistry & Scale-up: Serves as a defined starting material or intermediate in the optimization and pilot-scale production of active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis Catalyst Ligand Precursor: Potential use in the development of novel chiral ligands or organocatalysts for enantioselective transformations.
• Fine Chemical & Specialty Material Production: A building block for advanced materials, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Item	Detail
Product Name	Bicyclo[3.1.0]Hexane-1-Carboxylic Acid, 4-Hydroxy-, Methyl Ester, (1Alpha,4Beta,5Alpha)-
CAS No.	172908-33-7
Molecular Formula	C9H12O3
Molecular Weight	168.19 g/mol
Synonyms	(1α,4β,5α)-4-Hydroxybicyclo[3.1.0]hexane-1-carboxylic acid methyl ester; Methyl (1α,4β,5α)-4-hydroxybicyclo[3.1.0]hexane-1-carboxylate; 4-Hydroxybicyclo[3.1.0]hexane-1-carboxylic acid methyl ester, (1alpha,4beta,5alpha)-; Bicyclo[3.1.0]hexane-1-carboxylic acid, 4-hydroxy-, methyl ester, (1α,4β,5α)-; 172908-33-7; Methyl 4-hydroxybicyclo[3.1.0]hexane-1-carboxylate (stereospecific)
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-1-Carboxylic Acid, 4-Hydroxy-, Methyl Ester, (1Alpha,4Beta,5Alpha)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity, meeting the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.