Description

Pyrrolo[2,3-B]Pyridin-1-Yl-Acetic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a fused heterocyclic structure. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology sectors seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitor drugs for oncology and inflammatory diseases.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex fused heterocyclic scaffolds.
• Research & Development: Employed in academic and industrial R&D for exploring new chemical entities and biological pathways.
• Process Chemistry: Serves as a starting material or intermediate in the optimization and scale-up of API manufacturing processes.
• Bioconjugation Chemistry: Potential use in creating labeled compounds or probes for biochemical studies due to its reactive ester group.

Basic Information

Product Name	Pyrrolo[2,3-B]Pyridin-1-Yl-Acetic Acid Methyl Ester
CAS No.	172647-94-8
Molecular Formula	C11H10N2O2
Molecular Weight	202.21 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine-1-acetic acid, methyl ester; Methyl 1H-pyrrolo[2,3-b]pyridine-1-acetate; Methyl pyrrolo[2,3-b]pyridin-1-ylacetate; 1-(Carboxymethyl)-1H-pyrrolo[2,3-b]pyridine methyl ester; Pyrrolo[2,3-b]pyridin-1-ylacetic acid methyl ester; 172647-94-8; 1H-Pyrrolo[2,3-b]pyridine-1-acetic acid methyl ester
EINECS	Contact for details

Quality Control

Our Pyrrolo[2,3-B]Pyridin-1-Yl-Acetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.