Description

tert-Butyl((4-Hydroxymethyl)Phenyl)(Methyl)Carbamate CAS NO 172353-84-3 is a high-purity, protected amino acid derivative characterized by its versatile hydroxymethyl and carbamate functional groups. This compound serves as a critical building block in modern organic synthesis, particularly for the controlled introduction of amine functionalities. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing active pharmaceutical ingredients (APIs) and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid derivative.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides orthogonal protection for amines in complex multi-functional molecule synthesis.
• Medicinal Chemistry Research: Employed in constructing focused libraries and structure-activity relationship (SAR) studies.
• Bioconjugation: The hydroxymethyl group offers a handle for further functionalization and linkage to other molecules or surfaces.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides.

Basic Information

Product Name	tert-Butyl((4-Hydroxymethyl)Phenyl)(Methyl)Carbamate
CAS No.	172353-84-3
Molecular Formula	C13H19NO3
Molecular Weight	237.29 g/mol
Synonyms	tert-Butyl N-methyl-N-[4-(hydroxymethyl)phenyl]carbamate; 4-[(tert-Butoxycarbonyl)(methyl)amino]benzyl alcohol; N-Boc-N-methyl-4-(hydroxymethyl)aniline; N-Methyl-N-(4-hydroxymethylphenyl)carbamic acid tert-butyl ester; Boc-N-Me-4-(hydroxymethyl)aniline; 1,1-Dimethylethyl N-methyl-N-[4-(hydroxymethyl)phenyl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl((4-Hydroxymethyl)Phenyl)(Methyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.