Description

(S)-Homopipecolic acid methyl ester is a high-purity chiral building block and intermediate of significant importance in modern synthetic chemistry. Its defined stereochemistry makes it a valuable scaffold for the development of novel pharmaceuticals and bioactive compounds. This product is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for applications requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Peptidomimetics Research: Used to construct constrained peptide analogs and protease inhibitors due to its piperidine-derived structure.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides and pesticides with chiral specificity.
• Catalyst and Ligand Development: Employed in the preparation of chiral catalysts and ligands for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and receptor binding.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high enantiomeric purity.

Basic Information

Product Name	(S)-Homopipecolic acid methyl ester
CAS No.	171866-64-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(S)-2-(Methoxycarbonyl)piperidineacetic acid; Methyl (S)-2-piperidineacetate; (S)-Piperidine-2-acetic acid methyl ester; (S)-Homopipecolate methyl ester; L-Homopipecolic acid methyl ester; (2S)-2-(Methoxycarbonylmethyl)piperidine; (S)-Methyl 2-(piperidin-2-yl)acetate
EINECS	Contact for details

Quality Control

Our (S)-Homopipecolic acid methyl ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.