Description

(R)-Methyl 2-(tert-Butyldimethylsilyloxy)Propanoate CAS NO 171230-81-2 is a high-value chiral building block and protected ester derivative, essential for the stereoselective synthesis of complex organic molecules. Its primary value lies in its role as a versatile intermediate for introducing the (R)-lactic acid moiety into target compounds while offering robust protection of the hydroxyl group. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and fine chemical industries for applications such as API synthesis, natural product chemistry, and the development of chiral ligands and catalysts.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and central nervous system disorders.
• Asymmetric Synthesis: Used in the preparation of chiral auxiliaries, ligands for catalysis, and other stereochemically defined building blocks.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products that contain (R)-configured lactate or related structural motifs.
• Peptidomimetics & Prodrug Development: Serves as a protected amino acid analog for constructing modified peptides and designing prodrug strategies.
• Agrochemical Research: Utilized in the development of chiral active ingredients for crop protection agents.
• Material Science: Potential monomer or modifier for creating specialty polymers with specific chiral properties.

Basic Information

Product Name	(R)-Methyl 2-(tert-Butyldimethylsilyloxy)Propanoate
CAS No.	171230-81-2
Molecular Formula	C10H22O3Si
Molecular Weight	218.37 g/mol
Synonyms	(R)-Methyl O-(tert-Butyldimethylsilyl)lactate; Methyl (R)-2-[(tert-Butyldimethylsilyl)oxy]propanoate; (R)-Methyl 2-[(tert-Butyldimethylsilyl)oxy]propionate; (R)-2-(tert-Butyldimethylsiloxy)propionic acid methyl ester; (R)-TBDMS Lactate Methyl Ester; (R)-O-TBDMS-Lactic Acid Methyl Ester; (R)-Methyl 2-(TBDMSO)propanoate
EINECS	Contact for details

Quality Control

Our (R)-Methyl 2-(tert-Butyldimethylsilyloxy)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.