Description

5-[n-(tert-Butoxycarbonyl)Amino]-2-Chloropyridine is a high-purity, protected amino pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing active pharmaceutical ingredients (APIs) and other nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small molecule therapeutic programs.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the chloropyridine moiety for biological activity.
• Peptide Mimetics & Conjugates: The Boc-protected amino group allows for selective deprotection and further functionalization in peptide chemistry.
• Ligand Synthesis: Serves as a precursor for nitrogen-donor ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the creation of tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex organic molecules for clients.

Basic Information

Product Name	5-[n-(tert-Butoxycarbonyl)Amino]-2-Chloropyridine
CAS No.	171178-45-3
Molecular Formula	C10H13ClN2O2
Molecular Weight	228.68 g/mol
Synonyms	5-[(tert-Butoxycarbonyl)amino]-2-chloropyridine; 2-Chloro-5-[(tert-butoxycarbonyl)amino]pyridine; 5-(Boc-amino)-2-chloropyridine; 2-Chloro-5-(Boc-amino)pyridine; tert-Butyl (5-chloropyridin-2-yl)carbamate; Boc-5-amino-2-chloropyridine; 5-Amino-2-chloropyridine Boc derivative; 171178-45-3
EINECS	Contact for details

Quality Control

Our 5-[n-(tert-Butoxycarbonyl)Amino]-2-Chloropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.