Description

5-Amino-2-Fluoro-Isonicotinic Acid CAS NO 171178-43-1 is a high-purity fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino and a carboxylic acid group on a fluorinated pyridine ring, makes it an invaluable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its conjugated system and functional groups.
• Chemical Biology Probes: Utilized to create fluorescent tags or molecular probes for studying biological processes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	5-Amino-2-Fluoro-Isonicotinic Acid
CAS No.	171178-43-1
Molecular Formula	C6H5FN2O2
Molecular Weight	156.11 g/mol
Synonyms	2-Fluoro-5-aminoisonicotinic acid; 5-Amino-2-fluoropyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 5-amino-2-fluoro-; Isonicotinic acid, 5-amino-2-fluoro-; AFIA; 2-Fluoro-5-aminopyridine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-2-Fluoro-Isonicotinic Acid is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry environment to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.