Description

5-tert-Butoxycarbonylamino-2-Fluoroisonicotinic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amino group and a fluorine substituent on a pyridine core. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its structure provides key reactivity and stability for subsequent coupling and deprotection steps. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and antiviral research. The CAS number for this compound is 171178-42-0.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those targeting kinase inhibition.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors for antiviral therapies.
• Chemical Biology & Proteomics: Serves as a precursor for synthesizing activity-based probes and molecular tags for protein labeling studies.
• Agrochemical Research: Employed in the discovery and development of new generation herbicides and fungicides with fluorinated pyridine motifs.
• Material Science: Acts as a monomer or functionalization agent in the creation of specialized polymers and liquid crystals.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Item	Detail
Product Name	5-tert-Butoxycarbonylamino-2-Fluoroisonicotinic Acid
CAS No.	171178-42-0
Molecular Formula	C11H13FN2O4
Molecular Weight	256.23 g/mol
Synonyms	Boc-5-Amino-2-fluoroisonicotinic Acid; 2-Fluoro-5-[(tert-butoxycarbonyl)amino]isonicotinic Acid; 5-[(tert-Butoxycarbonyl)amino]-2-fluoropyridine-4-carboxylic Acid; 5-(Boc-amino)-2-fluoroisonicotinic Acid; 2-Fluoro-5-Boc-aminoisonicotinic Acid; 4-Pyridinecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-2-fluoro-; 171178-42-0
EINECS	Contact for details

Quality Control

Our 5-tert-Butoxycarbonylamino-2-Fluoroisonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.