Description

tert-Butyl 4-Fluoro-3-Methylbenzoate is a high-purity, synthetically valuable benzoate ester derivative, serving as a critical protected intermediate in advanced organic synthesis. Its primary commercial value lies in enabling the efficient construction of complex molecules, particularly in the pharmaceutical sector, where the tert-butyl ester group offers strategic advantages in multi-step synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality building blocks for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key protected carboxylic acid synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging the stability of the tert-butyl ester.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic compounds used in electronic display and lighting technologies.
• Polymer Modification: Employed to introduce fluorinated benzoate functionalities into specialty polymers to alter surface properties and stability.
• Organic Synthesis Reagent: Utilized in academic and industrial R&D for constructing complex molecular architectures via coupling reactions and further functional group transformations.
• Protecting Group Strategy: The tert-butyl ester group provides orthogonal protection in multi-step synthetic sequences, which can be cleaved under specific acidic conditions.

Basic Information

Product Name	tert-Butyl 4-Fluoro-3-Methylbenzoate
CAS No.	171050-00-3
Molecular Formula	C₁₂H₁₅FO₂
Molecular Weight	210.24 g/mol
Synonyms	4-Fluoro-3-methylbenzoic acid tert-butyl ester; Benzoic acid, 4-fluoro-3-methyl-, 1,1-dimethylethyl ester; tert-Butyl 4-fluoro-m-toluate; 1,1-Dimethylethyl 4-fluoro-3-methylbenzoate; 4-Fluoro-3-methyl-benzoic acid tert-butyl ester; t-Butyl 4-fluoro-3-methylbenzoate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Fluoro-3-Methylbenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of our global clientele. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.