Description

Ethyl (S)-3-Benzylpiperidine-3-Carboxylate is a high-value, optically active chiral building block and intermediate of significant importance in modern synthetic organic chemistry. Its defined stereochemistry and functionalized piperidine core make it a critical precursor for the development of novel pharmaceuticals and bioactive compounds. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and neurological targets.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex, enantiomerically pure molecules in catalytic and stoichiometric asymmetric transformations.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the 3-benzylpiperidine moiety into potential drug candidates.
• Agrochemical Research: Employed in the synthesis of novel chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Catalyst and Ligand Development: Acts as a precursor for the synthesis of chiral ligands and organocatalysts used in enantioselective reactions.
• Academic and R&D Laboratories: Utilized in fundamental research exploring new synthetic methodologies and the properties of chiral piperidine derivatives.

Basic Information

Product Name	Ethyl (S)-3-Benzylpiperidine-3-Carboxylate
CAS No.	170844-45-8
Molecular Formula	C15H21NO2
Molecular Weight	247.33 g/mol
Synonyms	(S)-Ethyl 3-Benzyl-3-piperidinecarboxylate; (S)-3-Benzyl-3-(ethoxycarbonyl)piperidine; (S)-1-Benzyl-3-(ethoxycarbonyl)piperidine-3-carboxylic Acid Ethyl Ester (tautomer); Ethyl (3S)-3-Benzylpiperidine-3-carboxylate; (S)-3-Benzylpiperidine-3-carboxylic Acid Ethyl Ester; (S)-3-Carbethoxy-3-benzylpiperidine; UNII-9J8K4V8H5M; 170844-45-8
EINECS	Contact for details

Quality Control

Our Ethyl (S)-3-Benzylpiperidine-3-Carboxylate is manufactured under strict quality control protocols to ensure high chemical and chiral purity, essential for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric excess (ee), and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for reliable, batch-to-batch consistency demanded by the pharmaceutical and fine chemical sectors.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.