Description

(3S)-1,3-Bis-o-tert-Butyldimethylsilyl 3-Hydroxy Vitamin D2 So2 Adduct (Mixture Of Diastereomers) is a key synthetic intermediate in the production of high-value vitamin D analogs and other steroidal pharmaceuticals. This compound is critical for researchers and manufacturers requiring precise control over stereochemistry and functional group protection in complex organic syntheses. Its primary utility is in the pharmaceutical and fine chemical industries for the development of new therapeutic agents and reference standards.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of advanced vitamin D2 derivatives and calcitriol analogs for osteoporosis and psoriasis treatments.
• Steroid Chemistry Research: Used in academic and industrial R&D for studying hydroxyl group protection/deprotection strategies and diastereoselective reactions.
• Process Development: Serves as a standardized intermediate for scaling up and optimizing manufacturing routes for vitamin D-based active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and impurity profiling.
• Fine Chemical Synthesis: Utilized in the preparation of other specialty chemicals where protected diol functionalities are required.

Basic Information

Product Name	(3S)-1,3-Bis-o-tert-Butyldimethylsilyl 3-Hydroxy Vitamin D2 So2 Adduct (Mixture Of Diastereomers)
CAS No.	170081-46-6
Molecular Formula	C39H70O4Si2S
Molecular Weight	691.2 g/mol
Synonyms	1,3-Bis-O-(tert-butyldimethylsilyl)-3-hydroxyvitamin D2 sulfur dioxide adduct; Vitamin D2 1,3-bis-TBS derivative SO2 adduct; (3S)-1,3-Bis-O-(tert-butyldimethylsilyl)ergocalciferol 3-ol sulfur dioxide adduct; TBS-protected Vitamin D2 SO2 adduct; 3-Hydroxy-1,3-bis-O-(tert-butyldimethylsilyl)vitamin D2 diastereomeric SO2 adduct; Steroid silyl ether SO2 complex; Ergocalciferol derivative, 1,3-bis(TBDMS) 3-hydroxy SO2 adduct
EINECS	Contact for details

Quality Control

Every batch of (3S)-1,3-Bis-o-tert-Butyldimethylsilyl 3-Hydroxy Vitamin D2 So2 Adduct is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and diastereomeric ratio conformity. Certificates of Analysis (COA) detailing all critical parameters are available for each lot to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (sum of diastereomers)
Diastereomeric Ratio (HPLC)	Specified on COA
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.