Description

2-[(4-Ethoxy-3-Methyl-2-Pyridinyl)-Methylsulfinyl]-Benzimidazole is a high-purity pharmaceutical intermediate of significant commercial and research importance. Its core value lies in its role as a key precursor in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in the proton pump inhibitor class. This compound is essential for manufacturers and R&D facilities in the global pharmaceutical and fine chemical industries seeking reliable, high-quality building blocks for complex drug synthesis. Consistent quality and supply chain integrity are paramount for its target applications.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of proton pump inhibitor (PPI) drugs and related benzimidazole-based therapeutics.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key precursor in multi-step synthesis routes for final drug substances in regulated manufacturing.
• Research & Development: Utilized in medicinal chemistry for the discovery and development of new gastrointestinal and acid-related disorder treatments.
• Process Chemistry & Scale-Up: Employed in pilot plants and commercial production for process optimization and validation of synthetic pathways.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.
• Fine Chemical Production: Used in the manufacture of other specialized, high-value chemical entities requiring this specific sulfinyl-benzimidazole scaffold.

Basic Information

Product Name	2-[(4-Ethoxy-3-Methyl-2-Pyridinyl)-Methylsulfinyl]-Benzimidazole
CAS No.	169905-00-4
Molecular Formula	C16H17N3O2S
Molecular Weight	315.39 g/mol
Synonyms	2-[[(4-Ethoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; 4-Ethoxy-3-methyl-2-[(1H-benzimidazol-2-ylsulfinyl)methyl]pyridine; Omeprazole Sulfide (Pyrmetazole); Omeprazole Impurity F (EP); Omeprazole Related Compound F (USP); 2-[(4-Ethoxy-3-methylpyridin-2-yl)methanesulfinyl]-1H-benzimidazole; H 168/68 Intermediate
EINECS	Contact for details

Quality Control

Our 2-[(4-Ethoxy-3-Methyl-2-Pyridinyl)-Methylsulfinyl]-Benzimidazole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets stringent specifications for pharmaceutical intermediate applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.