Description

4-Chloro-5-Fluoro-2-Methylpyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an exceptionally valuable intermediate for constructing complex molecules with tailored biological and physical properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance bioactivity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions, crucial for fine chemical manufacturing.
• Material Science Research: Employed in the creation of functionalized polymers and advanced organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and route scouting.

Basic Information

Product Name	4-Chloro-5-Fluoro-2-Methylpyridine
CAS No.	169750-95-2
Molecular Formula	C6H5ClFN
Molecular Weight	145.56 g/mol
Synonyms	2-Methyl-4-chloro-5-fluoropyridine; 5-Fluoro-4-chloro-2-picoline; 4-Chloro-5-fluoro-2-picoline; 2-Picoline, 4-chloro-5-fluoro-; 4-Chloro-5-fluoro-2-methylpyridine; 169750-95-2
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-5-Fluoro-2-Methylpyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.