Description

2-(4-Chloro-5-Fluoro-3-Methylpyridin-2-Yl)-2-Cyclopropylacetonitrile is a high-purity, advanced pharmaceutical intermediate with a distinct pyridine core structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Serves as a precursor for developing new-generation pesticides and herbicides with enhanced efficacy and selectivity.
• Chemical Synthesis: Used in organic synthesis for constructing fused pyridine ring systems and introducing the cyclopropylacetonitrile moiety into target molecules.
• Material Science Research: Investigated as a potential monomer or ligand for creating specialized polymers and coordination complexes.

Basic Information

Product Name	2-(4-Chloro-5-Fluoro-3-Methylpyridin-2-Yl)-2-Cyclopropylacetonitrile
CAS No.	169749-86-4
Molecular Formula	C11H10ClFN2
Molecular Weight	224.66 g/mol
Synonyms	2-Cyclopropyl-2-(4-chloro-5-fluoro-3-methyl-2-pyridinyl)acetonitrile; 2-(4-Chloro-5-fluoro-3-methylpyridin-2-yl)-2-cyclopropylacetonitrile; 2-Cyclopropyl-2-(4-chloro-5-fluoro-3-methylpyridin-2-yl)acetonitrile; 4-Chloro-5-fluoro-3-methyl-2-pyridineacetonitrile, α-cyclopropyl-; α-Cyclopropyl-4-chloro-5-fluoro-3-methyl-2-pyridineacetonitrile; 169749-86-4; 2-(4-Chloro-5-fluoro-3-methyl-2-pyridinyl)-2-cyclopropylacetonitrile
EINECS	Contact for details

Quality Control

Our production of 2-(4-Chloro-5-Fluoro-3-Methylpyridin-2-Yl)-2-Cyclopropylacetonitrile adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.