Description

(S)-(+)-1,1''-Bi-2-Naphthol Diacetate is a high-purity, enantiomerically pure derivative of 1,1'-Bi-2-naphthol (BINOL), a privileged chiral scaffold in asymmetric synthesis. This compound serves as a versatile chiral intermediate and protecting group precursor, enabling the synthesis of complex, optically active molecules with high enantiomeric excess. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality chiral building blocks for catalysis, ligand synthesis, and active pharmaceutical ingredient (API) development.

Application

• Chiral Ligand Synthesis: A key precursor for synthesizing enantiopure phosphoric acid catalysts, phosphoramidites, and other BINOL-derived ligands used in asymmetric catalysis.
• Pharmaceutical Intermediates: Employed in the research and production of chiral drugs, particularly in constructing axially chiral biaryl systems present in many therapeutic agents.
• Asymmetric Catalysis: Used to prepare catalysts for a wide range of enantioselective reactions, including hydrogenation, carbon-carbon bond formation, and Diels-Alder reactions.
• Material Science: A building block for chiral polymers, liquid crystals, and molecular recognition systems where optical activity is a critical property.
• Agrochemical Development: Utilized in creating enantiomerically pure pesticides and herbicides to improve efficacy and reduce environmental impact.
• Academic & Industrial R&D: A standard reagent for method development and discovery chemistry in laboratories focused on stereochemistry.

Basic Information

Product Name	(S)-(+)-1,1''-Bi-2-Naphthol Diacetate
CAS No.	169557-36-2
Molecular Formula	C24H18O4
Molecular Weight	370.40 g/mol
Synonyms	(S)-(+)-1,1'-Bi-2-naphthol Diacetate; (S)-BINOL Diacetate; (S)-1,1'-Binaphthalene-2,2'-diyl Diacetate; (S)-2,2'-Diacetoxy-1,1'-binaphthyl; (S)-H8-BINOL Diacetate (common for related derivatives); DA-BINOL (S); (S)-(-)-1,1'-Bi-2-naphthol Diacetate (Note: Check specific rotation sign convention)
EINECS	Contact for details

Quality Control

Our (S)-(+)-1,1''-Bi-2-Naphthol Diacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and standard purity assays. Certificates of Analysis (COA) detailing identity, purity (typically ≥98%), chiral excess (typically ≥99% ee), and impurity profiles are provided with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain chemical integrity and chiral purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.