Description

L-Isoleucine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (R)- (9Ci) is a specialized, high-purity derivative of the essential amino acid L-isoleucine, designed for advanced chemical synthesis and pharmaceutical research. This compound serves as a critical protected intermediate or building block in the synthesis of complex peptides, peptidomimetics, and other bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring precise stereochemistry and functional group protection for their synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel therapeutic peptides and protease inhibitors.
• Peptide Chemistry Research: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate protected L-isoleucine residues.
• Bioconjugation & Probe Development: Serves as a starting material for creating labeled amino acids or molecular probes for biochemical studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new drug candidates with optimized properties.
• Fine Chemical Synthesis: Acts as a precursor for the preparation of more complex, non-natural amino acids and derivatives.
• Academic & Industrial R&D: Essential for research in organic chemistry, biochemistry, and drug discovery programs focusing on peptide-based therapeutics.

Basic Information

Product Name	L-Isoleucine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (R)- (9Ci)
CAS No.	169533-20-4
Molecular Formula	C14H26N2O3
Molecular Weight	270.37 g/mol
Synonyms	(R)-N-[(tert-Butoxycarbonyl)amino]-3-methyl-L-valine methyl ester; Boc-L-isoleucine methyl ester (common misnomer for protected derivative); Methyl (2R)-2-[[(tert-butoxycarbonyl)amino]-3-methylpentanoate (related isomer); N-Boc-L-isoleucine methyl ester derivative; tert-Butyl N-[(1R)-1-(methoxycarbonyl)-2-methylbutyl]carbamate; Protected L-Isoleucine methyl ester; Amino acid derivative CAS 169533-20-4; BOC-Ile-OMe (specific notation for this compound)
EINECS	Contact for details

Quality Control

Our L-Isoleucine derivative is produced under strict quality management systems to ensure batch-to-batch consistency for critical research and synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity (typically >97%), and specific impurities is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% (R-configuration)
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.