Description

Bis(2-((tert-Butyldimethylsilyl)Oxy)Ethyl)Amine CAS NO 169527-49-5 is a specialized organosilicon-protected amine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its dual silyl-protected hydroxyl groups, which provide orthogonal protection strategies and enable selective reactions in complex molecule construction. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly in nucleoside and nucleotide chemistry where selective protection is required.
• Peptide Mimetics & Linker Chemistry: Used to create spacer arms and functional handles in bioconjugation and the development of peptide-like therapeutic agents.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and plant growth regulators requiring specific amine functionality.
• Polymer & Material Science: Monomer or functionalization agent for creating specialty silicones, coatings, and polymers with tailored surface properties.
• Ligand & Catalyst Development: Precursor for synthesizing novel chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Protecting Group Strategy: Employed in multi-step organic synthesis to protect diol or amino alcohol functionalities under conditions where other protecting groups are labile.

Basic Information

Product Name	Bis(2-((tert-Butyldimethylsilyl)Oxy)Ethyl)Amine
CAS No.	169527-49-5
Molecular Formula	C16H39NO2Si2
Molecular Weight	333.67 g/mol
Synonyms	N,N-Bis[2-[(tert-butyldimethylsilyl)oxy]ethyl]amine; 2,2'-[(Tert-butyldimethylsilyl)oxy]diethylamine; Bis(2-((tert-butyldimethylsilyl)oxy)ethyl)amine; N,N-Bis(2-((TBDMS)oxy)ethyl)amine; 1,1'-(Azanedyl)bis(2-((tert-butyldimethylsilyl)oxy)ethane); TBDMS-protected diethanolamine derivative; N,N-Bis(2-(tert-butyldimethylsiloxy)ethyl)amine
EINECS	Contact for details

Quality Control

Our Bis(2-((tert-Butyldimethylsilyl)Oxy)Ethyl)Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can compromise product integrity. Keep away from incompatible materials such as strong acids and oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.