Description

n-Boc-4-(2-Bromo-Ethyl)-Piperidine is a high-value, protected piperidine derivative that serves as a critical building block in modern organic synthesis. Its core value lies in the strategic combination of a bromoethyl handle for alkylation and a Boc-protected amine, enabling precise and sequential functionalization. This compound is essential for medicinal chemists and process development scientists engaged in the synthesis of complex molecules, particularly in pharmaceutical research for developing new active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of piperidine-based drug candidates, including potential CNS agents, receptor modulators, and kinase inhibitors.
• Peptidomimetic Chemistry: Used to introduce constrained, nitrogen-containing scaffolds that mimic peptide secondary structures, enhancing metabolic stability and bioavailability.
• Ligand and Probe Synthesis: Employed in the development of chemical probes, tool compounds, and ligands for biological target validation and assay development.
• Library Synthesis for Drug Discovery: A versatile building block for creating diverse compound libraries via parallel synthesis and combinatorial chemistry approaches.
• Agrochemical Research: Utilized in the research and development of novel agrochemicals that incorporate the piperidine motif for enhanced activity.
• Material Science Precursor: Can serve as an intermediate for synthesizing functionalized monomers or ligands for advanced polymers and coordination complexes.

Basic Information

Product Name	n-Boc-4-(2-Bromo-Ethyl)-Piperidine
CAS No.	169457-73-2
Molecular Formula	C12H22BrNO2
Molecular Weight	292.21 g/mol
Synonyms	1-Boc-4-(2-Bromoethyl)piperidine; tert-Butyl 4-(2-bromoethyl)piperidine-1-carboxylate; 4-(2-Bromoethyl)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 4-(2-Bromoethyl)piperidine-1-carboxylic Acid tert-Butyl Ester; N-Boc-4-(2-bromoethyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(2-bromoethyl)piperidine; Boc-4-(2-Bromoethyl)piperidine
EINECS	Contact for details

Quality Control

Our n-Boc-4-(2-Bromo-Ethyl)-Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.