Description

Glycine, n-[n-[2-Methoxy-2-Oxo-1-(Phenylmethyl)Ethyl]-L-Phenylalanyl]-, Methyl Ester, (S)- (9Ci) CAS NO 169453-00-3 is a specialized, optically active peptide derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its precise stereochemistry and functional groups, which make it an essential intermediate for constructing complex molecular architectures. This compound is primarily needed by pharmaceutical research and development organizations and fine chemical manufacturers focused on producing novel active pharmaceutical ingredients (APIs) and bioactive peptides.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel peptide-based therapeutics and protease inhibitors.
• Research Chemical: Used in academic and industrial R&D for studying enzyme-substrate interactions and developing new synthetic methodologies.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Combinatorial Chemistry: A valuable scaffold for generating diverse compound libraries in drug discovery programs.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis due to its defined (S)-configuration.

Basic Information

Product Name	Glycine, n-[n-[2-Methoxy-2-Oxo-1-(Phenylmethyl)Ethyl]-L-Phenylalanyl]-, Methyl Ester, (S)- (9Ci)
CAS No.	169453-00-3
Molecular Formula	C22H26N2O5
Molecular Weight	398.45 g/mol
Synonyms	N-[N-[2-Methoxy-2-oxo-1-(phenylmethyl)ethyl]-L-phenylalanyl]glycine methyl ester; (S)-Glycine, N-[N-[2-methoxy-2-oxo-1-(phenylmethyl)ethyl]-L-phenylalanyl]-, methyl ester; Benzyl N-[(2S)-1-[[(2S)-2-(methoxycarbonylamino)-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate; A protected dipeptide derivative; Gly-Phe(OBzl) methyl ester analog; Boc-Phe-Gly-OMe related intermediate. Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development and cGMP manufacturing needs with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.