Description

L-Phenylalanine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (S)- (9Ci) CAS NO 169452-98-6 is a sophisticated, high-purity chiral building block and protected amino acid derivative. This compound is critical for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery and development of therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce protected phenylalanine residues with specific side-chain modifications.
• Protease Inhibitor Research: Acts as a core structural component in the development of protease inhibitors due to its specific stereochemistry and functional groups.
• Bioconjugation & Labeling: Employed in the preparation of modified peptides for bioconjugation, diagnostic probes, and targeted drug delivery systems.
• Academic & Industrial R&D: Essential for medicinal chemistry programs focused on structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: Provides a versatile starting point for contract research organizations (CROs) and CDMOs performing custom synthesis of complex organic molecules.

Basic Information

Product Name	L-Phenylalanine, n-[1-[[(1,1-Dimethylethyl)Amino]Carbonyl]-2-Methylpropyl]-, Methyl Ester, (S)- (9Ci)
CAS No.	169452-98-6
Molecular Formula	C17H26N2O3
Molecular Weight	306.40 g/mol
Synonyms	Boc-L-Phe(4-Me)-OMe; (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate (common mis-assignment for simpler analog); N-(tert-Butoxycarbonyl)-L-phenylalanine methyl ester (related core structure); Boc-Phe-OMe derivative; N-Boc-L-Phenylalanine methyl ester analog; tert-Butyl ((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamate derivative; Protected L-Phenylalanine methyl ester; Peptide synthesis building block CAS 169452-98-6
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality system supports compliance with cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.