Description

tert-Butyl [5-(Hydroxymethyl)Pyridin-2-Yl)Carbamate is a versatile and high-purity chemical building block, primarily utilized as a key intermediate in advanced organic synthesis. Its value lies in its bifunctional structure, featuring both a protected amine (carbamate) and a hydroxymethyl group, which allows for selective and sequential derivatization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially in kinase inhibitor and antiviral research.
• Peptide Mimetics & PROTACs: Used to construct complex molecular architectures for targeted protein degradation and peptide-based therapeutics.
• Agrochemical Synthesis: Serves as a precursor in the development of new pesticides and herbicides with enhanced efficacy.
• Ligand & Catalyst Development: Employed in creating specialized ligands for metal catalysis and asymmetric synthesis.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific, high-value intermediates under cGMP conditions.

Basic Information

Product Name	tert-Butyl [5-(Hydroxymethyl)Pyridin-2-Yl)Carbamate
CAS No.	169280-83-5
Molecular Formula	C11H16N2O3
Molecular Weight	224.26 g/mol
Synonyms	2-Pyridinecarboxamide, N-(1,1-dimethylethoxy)carbonyl-5-(hydroxymethyl)-; 5-(Hydroxymethyl)-2-pyridinylcarbamic acid tert-butyl ester; tert-Butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate; 2-((tert-Butoxycarbonyl)amino)-5-(hydroxymethyl)pyridine; Boc-APC-OH; Boc-5-(hydroxymethyl)pyridin-2-amine; N-Boc-5-(hydroxymethyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Our tert-Butyl [5-(Hydroxymethyl)Pyridin-2-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high standards, from research and development to pre-clinical and clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.