Description

L-Proline, 3-Amino-, Methyl Ester, (3R)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative characterized by its chiral (3R) configuration and ester functionalization. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures with precise stereochemical control. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other therapeutic compounds.
• Peptidomimetics Research: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability and biological activity.
• Asymmetric Catalysis: Serves as a precursor for ligands and organocatalysts used in enantioselective synthesis.
• Chemical Biology Probes: Employed in the development of labeled compounds and molecular probes for studying enzyme mechanisms and protein interactions.
• Agrochemical Synthesis: An intermediate in the production of advanced, chiral active ingredients for crop protection.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry projects.

Basic Information

Product Name	L-Proline, 3-Amino-, Methyl Ester, (3R)- (9Ci)
CAS No.	169061-54-5
Molecular Formula	C7H12N2O3
Molecular Weight	172.18 g/mol
Synonyms	(3R)-3-Aminopyrrolidine-2-carboxylic acid methyl ester; Methyl (3R)-3-aminopyrrolidine-2-carboxylate; (R)-Methyl 3-aminopyrrolidine-2-carboxylate; (R)-3-Amino-L-proline methyl ester; (R)-3-Aminoproline methyl ester; (R)-2-Carbomethoxy-3-aminopyrrolidine; (R)-3-Azaprolinenitrile derivative
EINECS	Contact for details

Quality Control

Our L-Proline, 3-Amino-, Methyl Ester, (3R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.