Description

2-[2-[2-(2-Azidoethoxy)Ethoxy]Ethoxy]-1-(p-Toluenesulfonyl)-Ethanol is a specialized bifunctional organic compound featuring a polyethylene glycol (PEG) linker terminated with an azide group and a tosyl-protected alcohol. This molecular architecture makes it a critical building block for advanced material synthesis and bioconjugation, particularly through click chemistry reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise, modular, and efficient methods for coupling molecules or functionalizing surfaces.

Application

• Click Chemistry Reagent: Serves as a key precursor for Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition, CuAAC) to create triazole linkages for polymer and dendrimer synthesis.
• Bioconjugation & Protein Labeling: Used to functionalize biomolecules (e.g., antibodies, peptides) with PEG spacers for improved solubility, stability, and pharmacokinetics.
• Surface Modification & Functionalization: Enables the grafting of azide-terminated PEG chains onto alkyne-modified surfaces (e.g., nanoparticles, chips, medical devices) to create biocompatible, non-fouling coatings.
• Pharmaceutical Intermediate: Acts as a versatile linker in the synthesis of prodrugs, antibody-drug conjugates (ADCs), and targeted therapeutic agents.
• Polymer & Material Science: A monomer or cross-linker for synthesizing functional hydrogels, smart materials, and responsive polymers with tailored properties.
• Diagnostic Reagent Synthesis: Employed in the development of diagnostic assays and imaging probes where stable, covalent attachment of signaling molecules is required.

Basic Information

Product Name	2-[2-[2-(2-Azidoethoxy)Ethoxy]Ethoxy]-1-(p-Toluenesulfonyl)-Ethanol
CAS No.	168640-82-2
Molecular Formula	C15H23N3O7S
Molecular Weight	389.42 g/mol
Synonyms	1-(p-Toluenesulfonyl)-2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol; 2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl 4-methylbenzenesulfonate; Azide-PEG3-Tosylate; Azido-PEG3-OTs; N3-PEG3-OTs; Tosyl-PEG3-azide; PEG3 Azide Tosylate; 4-Methylbenzenesulfonic Acid 2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl Ester
EINECS	Contact for details

Quality Control

Our production of 2-[2-[2-(2-Azidoethoxy)Ethoxy]Ethoxy]-1-(p-Toluenesulfonyl)-Ethanol adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and commercial applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storing under an inert gas (argon or nitrogen) atmosphere. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.