Description

tert-Butyl-2-Bromonicotinate is a high-value brominated nicotinate ester derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a versatile and reactive scaffold for constructing complex heterocyclic molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce functionalized pyridine motifs into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing functionalized pyridine or nicotinic acid derivatives.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or light-emitting components.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Nucleophilic Substitution: The bromine atom offers a site for nucleophilic substitution, enabling further functionalization of the pyridine ring.

Basic Information

Product Name	tert-Butyl-2-Bromonicotinate
CAS No.	168629-64-9
Molecular Formula	C10H12BrNO2
Molecular Weight	258.11 g/mol
Synonyms	2-Bromonicotinic Acid tert-Butyl Ester; tert-Butyl 2-Bromopyridine-3-carboxylate; 3-Pyridinecarboxylic Acid, 2-Bromo-, 1,1-Dimethylethyl Ester; 2-Bromo-3-(tert-butoxycarbonyl)pyridine; 2-Bromonicotinic Acid t-Butyl Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl-2-Bromonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to exclude moisture and stored away from direct light sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.