Description

1-Azido-2-Hydroxy-3-Tosyloxypropane CAS NO 168431-73-0 is a versatile bifunctional organic intermediate containing both an azide and a tosylate leaving group, enabling diverse click chemistry and nucleophilic substitution reactions. This compound is critical for researchers and manufacturers requiring precise molecular scaffolds for the synthesis of complex molecules, including pharmaceuticals, agrochemicals, and advanced materials. It is particularly valuable for chemists in pharmaceutical R&D, fine chemical synthesis, and academic research focused on developing new bioactive compounds and polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those incorporating triazole rings via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC).
• Click Chemistry Reagent: Serves as a fundamental azide component in click chemistry applications for bioconjugation, polymer functionalization, and material surface modification.
• Glycoconjugate Synthesis: Used in the preparation of glycosyl donors and other carbohydrate derivatives for drug discovery and biochemical studies.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating functional polymers with tailored properties for specialty coatings and hydrogels.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Utilized for labeling and tracking biomolecules in diagnostic assays and cellular imaging studies.

Basic Information

Item	Detail
Product Name	1-Azido-2-Hydroxy-3-Tosyloxypropane
CAS No.	168431-73-0
Molecular Formula	C10H13N3O4S
Molecular Weight	271.29 g/mol
Synonyms	2-Hydroxy-3-tosyloxypropyl azide; 3-Azido-2-hydroxypropyl 4-methylbenzenesulfonate; 1-Azido-3-tosyloxy-2-propanol; Glycidyl tosylate azide adduct; Azidohydroxy tosyloxypropane; Tosyloxy azido propanol; (2-Hydroxy-3-tosyloxypropyl)azide
EINECS	Contact for details

Quality Control

Our 1-Azido-2-Hydroxy-3-Tosyloxypropane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of our global customer base in advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials. Due to the presence of an organic azide group, handle and store with appropriate precautions, avoiding shock, friction, and confinement.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.