Description

2-Propyl-3-[[4-[3-(2H-Tetrazol-5-Yl)Pyridin-2-Yl]Phenyl]Methyl]-1,5,7, 9-Tetrazabicyclo[4.3.0]Nona-2,5,7-Trien-4-One is a high-purity, complex heterocyclic compound featuring fused tetrazole and pyridine rings, which are critical pharmacophores in medicinal chemistry. This compound serves as a key advanced intermediate for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting specific enzymatic pathways. It is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in synthesizing next-generation drug candidates, where precise molecular structure and purity are paramount for biological activity and regulatory success.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of investigational new drugs, especially those targeting cardiovascular and metabolic disorders.
• Angiotensin II Receptor Antagonist Research: Core structural component for developing sartan-class drug candidates due to the presence of the biphenyl-tetrazole moiety.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Biochemical Research: Serves as a reference standard or a ligand in enzymatic assays and receptor binding studies.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct complex molecular architectures for specialized applications.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Item	Details
Product Name	2-Propyl-3-[[4-[3-(2H-Tetrazol-5-Yl)Pyridin-2-Yl]Phenyl]Methyl]-1,5,7, 9-Tetrazabicyclo[4.3.0]Nona-2,5,7-Trien-4-One
CAS No.	168152-81-6
Molecular Formula	C22H21N9O
Molecular Weight	427.47 g/mol
Synonyms	Valsartan Impurity; Valsartan Related Compound; 2-Propyl-3-{[4-[3-(2H-tetrazol-5-yl)pyridin-2-yl]phenyl]methyl}-1,5,7,9-tetrazabicyclo[4.3.0]nona-2,5,7-trien-4-one; 1,5,7,9-Tetrazabicyclo[4.3.0]nona-2,5,7-trien-4-one, 2-propyl-3-[[4-[3-(2H-tetrazol-5-yl)-2-pyridinyl]phenyl]methyl]-; Bicyclic Valsartan Intermediate
EINECS	Contact for details

Quality Control

Our 2-Propyl-3-[[4-[3-(2H-Tetrazol-5-Yl)Pyridin-2-Yl]Phenyl]Methyl]-1,5,7, 9-Tetrazabicyclo[4.3.0]Nona-2,5,7-Trien-4-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing compliance with client specifications and relevant ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.