Description

(S)-2-(Azidomethyl)-1-Boc-Pyrrolidine is a high-purity, chiral building block of significant importance in modern organic synthesis. This compound is specifically designed for the efficient construction of complex molecules, offering a protected amine and a versatile azide functional group for further derivatization. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for protease inhibitors and other small molecule therapeutics.
• Peptidomimetic Chemistry: Used to introduce constrained pyrrolidine scaffolds and azide handles for "click chemistry" in the design of peptide mimics.
• Agrochemical Research: Serves as a building block for developing novel, chiral active ingredients with specific biological activity.
• Chemical Biology & Bioconjugation: The azide group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling and conjugating biomolecules.
• Material Science: Potential monomer or cross-linker for creating functional polymers with tailored properties.
• Academic & Process R&D: A valuable reagent for methodological development in asymmetric synthesis and route scouting.

Basic Information

Product Name	(S)-2-(Azidomethyl)-1-Boc-Pyrrolidine
CAS No.	168049-26-1
Molecular Formula	C11H20N4O2
Molecular Weight	240.30 g/mol
Synonyms	1-Boc-2-(azidomethyl)-(S)-pyrrolidine; tert-Butyl (2S)-2-(azidomethyl)pyrrolidine-1-carboxylate; (S)-1-(tert-Butoxycarbonyl)-2-(azidomethyl)pyrrolidine; (S)-2-(Azidomethyl)-1-(tert-butoxycarbonyl)pyrrolidine; (S)-N-Boc-2-(azidomethyl)pyrrolidine; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-2-(azidomethyl)pyrrolidine; (S)-1-Boc-2-azidomethylpyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-2-(Azidomethyl)-1-Boc-Pyrrolidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.