Description

4-Isocyanato-n-Methylbenzenesulfonamide is a specialized aromatic isocyanate derivative, serving as a key reactive intermediate in advanced organic synthesis. Its value lies in the unique combination of a reactive isocyanate group and a sulfonamide moiety, enabling the controlled introduction of functional groups to build complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel sulfonamide-based drug candidates, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the sulfonamide group contributes to biological activity.
• Polymer & Resin Modification: Serves as a cross-linking agent or chain extender in specialty polyurethanes and coatings, enhancing chemical resistance and mechanical properties.
• Chemical Research & Development: A versatile reagent for constructing urea and carbamate linkages in medicinal chemistry and material science projects.
• Dye & Pigment Manufacturing: Employed in the synthesis of specialized colorants and functional dyes requiring sulfonamide groups for solubility or fastness.

Basic Information

Product Name	4-Isocyanato-n-Methylbenzenesulfonamide
CAS No.	167951-45-3
Molecular Formula	C8H8N2O3S
Molecular Weight	212.23 g/mol
Synonyms	4-Isocyanato-N-methylbenzenesulfonamide; N-Methyl-4-isocyanatobenzenesulfonamide; p-Isocyanato-N-methylbenzenesulfonamide; Benzenesulfonamide, N-methyl-4-isocyanato-; 4-Isocyanato-N-methylbenzene-1-sulfonamide; Tosyl isocyanate, N-methyl derivative; Methyl(4-isocyanatophenyl)sulfonylamine
EINECS	Contact for details

Quality Control

Our production of 4-Isocyanato-n-Methylbenzenesulfonamide adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthesis. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.