Description

1-[(4-Chloro-2-Pyridinyl)Carbonyl]Proline is a high-purity, advanced pharmaceutical intermediate characterized by its specific proline-derived structure. This compound is of significant value in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents and fine chemical synthesis.

Application

• Key Intermediate in API Synthesis: Serves as a critical building block for the production of sophisticated active pharmaceutical ingredients.
• Neurological & Cardiovascular Drug Research: Used in the R&D of new drug candidates targeting specific receptors in these therapeutic areas.
• Peptidomimetic & Protease Inhibitor Development: Integral to creating molecules that mimic peptides or inhibit specific enzymes.
• Fine Chemical and Custom Synthesis: Employed in contract manufacturing and custom synthesis projects requiring high-purity, specialized intermediates.
• Bioconjugation & Labeling Chemistry: Potential use in creating conjugates for diagnostic or targeted drug delivery applications.
• Academic & Industrial Research: Utilized in chemical biology and medicinal chemistry programs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	1-[(4-Chloro-2-Pyridinyl)Carbonyl]Proline
CAS No.	167868-27-1
Molecular Formula	C11H11ClN2O3
Molecular Weight	254.67 g/mol
Synonyms	L-Proline, 1-[(4-chloro-2-pyridinyl)carbonyl]-; (S)-1-((4-Chloropyridin-2-yl)carbonyl)pyrrolidine-2-carboxylic acid; 4-Chloro-2-pyridinecarboxylic acid proline amide; 1-[(4-Chloro-2-pyridinyl)carbonyl]-L-proline; Proline, 1-[(4-chloro-2-pyridinyl)carbonyl]-, L-; UNII-9V2I8T2J8R; 9V2I8T2J8R; 1-(4-Chloro-pyridine-2-carbonyl)-pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-[(4-Chloro-2-Pyridinyl)Carbonyl]Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) documenting purity, related substances, and other critical parameters are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider conditions under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.