Description

n-(Pyridine-2-Carbonyl)-L-Proline is a specialized chiral organic compound that serves as a high-value building block in advanced chemical synthesis. Its unique structure, combining a proline moiety with a pyridine carbonyl group, makes it a critical intermediate for creating complex molecules with specific stereochemistry. This product is essential for research and development in the pharmaceutical and agrochemical sectors, where precise molecular architecture is required for developing new active ingredients. Its reliable quality and consistent performance support innovation in drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other enzyme-targeted therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where specific stereochemistry influences biological activity and environmental safety.
• Catalyst Ligand Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetic Research: Employed in medicinal chemistry for constructing peptidomimetics and conformationally constrained peptide analogs to improve metabolic stability.
• Biochemical Probe Development: Utilized in academic and industrial research to create molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Fine Chemical Production: Acts as a building block for custom synthesis and contract manufacturing of high-value, low-volume specialty chemicals.

Basic Information

Product Name	n-(Pyridine-2-Carbonyl)-L-Proline
CAS No.	167868-25-9
Molecular Formula	C11H10N2O3
Molecular Weight	218.21 g/mol
Synonyms	L-Proline, 1-[(2-pyridinylcarbonyl)]-; 1-(Pyridine-2-carbonyl)-L-proline; (S)-1-(Pyridine-2-carbonyl)pyrrolidine-2-carboxylic acid; N-Picolinoyl-L-proline; N-(2-Pyridylcarbonyl)-L-proline; N-(Pyridin-2-ylcarbonyl)-L-proline; 2-Pyridinecarboxylic acid, 1-L-prolyl-; 167868-25-9
EINECS	Contact for details

Quality Control

Our n-(Pyridine-2-Carbonyl)-L-Proline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of research and cGMP-grade production environments. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and chiral purity are provided with every shipment. We support compliance with global regulatory standards, and specifications can be aligned with customer-specific pharmacopeial or internal quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.