Description

3-Oxo-3-(1-Cbz-Piperidin-4-Yl)-Propionic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold protected by a carboxybenzyl (Cbz) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disorder treatments.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those targeting protease inhibition or G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Peptidomimetic Synthesis: Employed in the construction of peptidomimetic compounds due to its piperidine core and ester functionality, which can mimic peptide bonds.
• API Development: Serves as a building block in the development route of Active Pharmaceutical Ingredients (APIs) requiring a protected amino-piperidine moiety.
• Chemical Biology Probes: Utilized in the synthesis of chemical probes for studying enzyme function and biological pathways in preclinical research.

Basic Information

Product Name	3-Oxo-3-(1-Cbz-Piperidin-4-Yl)-Propionic Acid Ethyl Ester
CAS No.	167414-75-7
Molecular Formula	C18H23NO5
Molecular Weight	333.38 g/mol
Synonyms	Ethyl 3-(1-[(benzyloxy)carbonyl]-4-piperidinyl)-3-oxopropanoate; 1-Cbz-4-(3-Ethoxy-3-oxopropanoyl)piperidine; 3-(1-Cbz-piperidin-4-yl)-3-oxo-propionic acid ethyl ester; 1-N-CBZ-4-(3-ETHOXY-3-OXOPROPANOYL)PIPERIDINE; 3-Oxo-3-(1-Cbz-4-piperidyl)propionic Acid Ethyl Ester; 3-Oxo-3-[1-(phenylmethoxy)carbonyl-4-piperidinyl]propanoic acid ethyl ester; Ethyl 3-oxo-3-[1-(phenylmethoxy)carbonyl-4-piperidinyl]propanoate
EINECS	Contact for details

Quality Control

Our 3-Oxo-3-(1-Cbz-Piperidin-4-Yl)-Propionic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.