Description

T-Butyl Chlorodifluoroacetate is a versatile fluorinated building block and reagent essential for introducing the chlorodifluoroacetate moiety into complex molecules. This compound matters for its role in facilitating efficient synthesis pathways, particularly in the development of pharmaceuticals and advanced materials where precise fluorination is critical. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to enhance the metabolic stability and bioavailability of their target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring difluoromethyl or trifluoromethyl groups.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorine atoms improve efficacy and environmental profile.
• Material Science: Employed in the creation of fluorinated polymers, coatings, and liquid crystals with enhanced chemical resistance and thermal stability.
• Organic Synthesis Reagent: Acts as a versatile reagent for esterification and acylation reactions under mild conditions.
• PET Tracer Precursor: Potential use in radiochemistry for synthesizing positron emission tomography (PET) imaging agents.
• Fluorine Chemistry Research: A valuable tool in academic and industrial R&D for exploring new fluorination methodologies and creating novel fluorinated compounds.

Basic Information

Item	Detail
Product Name	T-Butyl Chlorodifluoroacetate
CAS No.	167308-43-2
Molecular Formula	C6H9ClF2O2
Molecular Weight	186.59 g/mol
Synonyms	tert-Butyl Chlorodifluoroacetate; Chlorodifluoroacetic Acid tert-Butyl Ester; 2-Chloro-2,2-difluoroacetic Acid 1,1-Dimethylethyl Ester; 1,1-Dimethylethyl Chlorodifluoroacetate; t-Bu Chlorodifluoroacetate; tert-Butyl 2-Chloro-2,2-difluoroacetate; Chlorodifluoroacetic Acid t-Butyl Ester
EINECS	Contact for details

Quality Control

Our T-Butyl Chlorodifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Incompatible with strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.2 g/mL
Boiling Point	~130-135°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.