Description

Ethyl 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is engineered to provide a versatile scaffold for constructing complex molecules, offering significant advantages in molecular diversity and property modulation. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Serves as a critical building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Used in the development of organic semiconductors, liquid crystals, and other functional materials due to its electron-deficient thiophene core and aromatic system.
• Chemical Synthesis: Acts as a versatile synthon for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) and other transformations to introduce complex thiophene motifs.
• Fluorine Chemistry: The trifluoromethyl group makes it a valuable reagent for introducing fluorine atoms into target molecules to improve metabolic stability, lipophilicity, and bioavailability.

Basic Information

Product Name	Ethyl 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate
CAS No.	167279-18-7
Molecular Formula	C14H11F3O2S
Molecular Weight	300.30 g/mol
Synonyms	Ethyl 4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 4-phenyl-5-(trifluoromethyl)-, ethyl ester; Ethyl 5-(trifluoromethyl)-4-phenylthiophene-2-carboxylate; 4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylic Acid Ethyl Ester; 167279-18-7; AKOS BRN 0971; CTK8G0668; NSC 405124; ZINC38516171
EINECS	Contact for details

Quality Control

Our Ethyl 4-Phenyl-5-(Trifluoromethyl)Thiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and rigorous in-process controls guarantees a reliable supply of high-purity material for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.