Description

Carbamic Acid, [(3-Hydroxycyclobutyl)Methyl]-, 1,1-Dimethylethyl Ester (9Ci) is a specialized organic compound featuring a carbamate-protected amine group and a cyclobutanol moiety, making it a valuable protected intermediate for advanced synthesis. This high-purity building block is critical for pharmaceutical research and development, enabling the controlled introduction of functional groups in complex molecules. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Peptide Mimetics & PROTACs: Serves as a versatile building block for constructing peptide backbones and linkers in proteolysis-targeting chimeras (PROTACs) due to its amine-protecting group and hydroxyl functionality.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a handle for selective deprotection and further functionalization.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where the carbamate and cyclobutyl structures are pharmacologically relevant.
• Ligand & Catalyst Development: Acts as a precursor for chiral ligands or catalysts in asymmetric synthesis, leveraging the stereochemistry of the cyclobutane ring.
• Polymer Science: Potential monomer or cross-linking agent for creating specialty polymers with unique thermal and mechanical properties.

Basic Information

Product Name	Carbamic Acid, [(3-Hydroxycyclobutyl)Methyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	167081-41-6
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	tert-Butyl N-[(3-hydroxycyclobutyl)methyl]carbamate; N-[(3-Hydroxycyclobutyl)methyl]carbamic Acid tert-Butyl Ester; N-Boc-3-(aminomethyl)cyclobutanol; (3-((tert-Butoxycarbonyl)amino)methyl)cyclobutanol; Boc-3-Aminomethylcyclobutanol; 1,1-Dimethylethyl N-[(3-hydroxycyclobutyl)methyl]carbamate; (3-Hydroxycyclobutyl)methylcarbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(3-Hydroxycyclobutyl)Methyl]-, 1,1-Dimethylethyl Ester (9Ci) adheres to stringent quality protocols suitable for GMP and ICH Q7 guidelines for pharmaceutical intermediates. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.