Description

2-Chloro-4-(Trifluoromethyl)Pyridin-3-Amine is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents, makes it an essential intermediate for creating compounds with tailored biological and physical properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands, organic electronic materials, and liquid crystals due to its electron-withdrawing characteristics.
• Chemical Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to construct complex heterocyclic systems.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where the pyridine core contributes to color fastness and unique chromophoric properties.

Basic Information

Item	Details
Product Name	2-Chloro-4-(Trifluoromethyl)Pyridin-3-Amine
CAS No.	166770-70-3
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	3-Amino-2-chloro-4-(trifluoromethyl)pyridine; 2-Chloro-4-trifluoromethyl-3-pyridinamine; 2-Chloro-4-(trifluoromethyl)-3-pyridinylamine; 2-Chloro-4-(trifluoromethyl)-3-aminopyridine; 3-Pyridinamine, 2-chloro-4-(trifluoromethyl)-; 166770-70-3; 2-Chloro-4-trifluoromethylpyridin-3-ylamine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Trifluoromethyl)Pyridin-3-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.