Description

Avasimibe CAS NO 166518-60-1 is a potent and selective inhibitor of the acyl-CoA:cholesterol acyltransferase (ACAT) enzyme, a key target in lipid metabolism research. This compound is crucial for investigating cholesterol absorption and esterification pathways, offering significant value for the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cardiovascular disease, atherosclerosis, and metabolic disorder studies.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) in preclinical studies for cardiovascular and metabolic diseases.
• Mechanistic Studies: For investigating the role of ACAT enzymes in intracellular cholesterol homeostasis and foam cell formation.
• Atherosclerosis Research: Used in in vitro and in vivo models to study the inhibition of cholesterol ester accumulation in arterial walls.
• Biochemical Assay Development: Serves as a critical control compound in high-throughput screening (HTS) assays to identify new ACAT inhibitors.
• Metabolic Disorder Investigation: Applied in research exploring the connection between cholesterol metabolism, insulin resistance, and related disorders.
• Academic Research: A vital tool for universities and research institutes conducting fundamental research in lipid biochemistry and pharmacology.

Basic Information

Product Name	Avasimibe
CAS No.	166518-60-1
Molecular Formula	C₂₉H₃₄F₃NO₄S
Molecular Weight	549.65 g/mol
Synonyms	CI-1011; PD-148515; (2R,3S)-N-(2,4-Difluorophenyl)-2-(3-fluorophenyl)-3-(4-fluorophenyl)-2-[(1-methylethyl)sulfonyl]butanamide; Avasimibe (CI-1011); Butanamide, N-(2,4-difluorophenyl)-2-(3-fluorophenyl)-3-(4-fluorophenyl)-2-[(1-methylethyl)sulfonyl]-, (2R,3S)-; ACAT inhibitor CI-1011
EINECS	Contact for details

Quality Control

Our Avasimibe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.